How To Use MI Paste Plus: A Clinical Guide To Remineralization And Desensitization

How To Use MI Paste Plus: A Clinical Guide To Remineralization And Desensitization

MI Paste Plus | GC Ortho

MI Paste Plus utilizes Recaldent technology, a casein phosphopeptide-amorphous calcium phosphate complex, to replenish mineral levels in enamel and reduce dentin hypersensitivity. For optimal clinical efficacy, it must be applied to clean, plaque-free teeth and allowed to remain in contact with the tooth surface for at least three minutes to facilitate ion diffusion and crystal structure stabilization.

Essential Preparation and Application Protocol

Successful remineralization therapy depends on the bioavailability of calcium and phosphate ions at the enamel-saliva interface. Before applying MI Paste Plus, the oral environment must be prepared to ensure the material is not inhibited by organic debris or plaque biofilms.



  • Required Materials: A pea-sized amount of MI Paste Plus, a soft-bristled toothbrush, a custom-fitted fluoride tray (optional, for localized treatment), or a clean finger.
  • Mandatory Prerequisites: Teeth must be thoroughly brushed and flossed immediately before application. The presence of food particles or plaque will physically prevent the CPP-ACP complex from contacting the enamel surface, rendering the application ineffective.
  • Duration Benchmarks: The paste should remain undisturbed in the oral cavity for a minimum of three to five minutes. Patients should avoid rinsing, eating, or drinking for at least 30 minutes following application to allow for maximum mineral uptake.
  • Safety Standards: Patients with a documented milk protein allergy (casein) or sensitivity to benzoate preservatives must strictly avoid this product due to the risk of anaphylactic or allergic reactions.

Procedural Workflow for Daily Remineralization

Applying MI Paste Plus requires consistent technique to ensure the paste reaches all interproximal areas and exposed cervical regions where sensitivity is most prevalent.



Step 1: Mechanical Plaque Removal

Perform a standard brushing and flossing routine. Use a non-abrasive toothpaste to ensure the enamel surface is clean but not etched by high-RDA (Relative Dentin Abrasivity) dentifrices. Dry the teeth surfaces slightly using a clean gauze pad if applying to specific sensitive areas, as excess saliva can prematurely dilute the paste.



Step 2: Precision Application

Squeeze a pea-sized amount of MI Paste Plus onto a clean finger or a customized application tray. If using your finger, gently smear the paste across the surfaces of all teeth, paying special attention to the gum line and areas of known recession.

Pro-Tip: If using a custom-fitted tray for widespread sensitivity, ensure the tray covers the cervical margins of the teeth, as this is where the cementum is often exposed and prone to fluid movement through dentinal tubules.



Step 3: Diffusion and Contact Time

Once the paste is distributed, use your tongue to spread it across all oral surfaces. Hold the paste in the mouth for three to five minutes. During this period, keep the mouth slightly open or use a saliva ejector if you are performing this in a clinical setting to prevent excessive saliva dilution.

Warning: Do not swallow the paste. While the product is non-toxic, swallowing excessive amounts can lead to gastrointestinal discomfort in sensitive individuals. Always expectorate any excess paste remaining after the contact period.



Step 4: Post-Application Maintenance

Do not rinse your mouth immediately after the contact period. Simply expectorate the excess material. The residual thin film of CPP-ACP left on the teeth will continue to provide protective mineral buffering throughout the immediate post-application phase. Refrain from consuming food or beverages for at least 30 minutes to ensure the minerals integrate into the hydroxyapatite structure of the enamel.


MIPaste Plus Vanilla

MIPaste Plus Vanilla

Technical Parameters and Material Efficacy

The efficacy of MI Paste Plus is measured by its ability to maintain a supersaturated state of calcium and phosphate ions within the oral environment. The addition of fluoride in the "Plus" formulation enhances the formation of fluorapatite, which is more resistant to acid challenges than natural hydroxyapatite.



Feature MI Paste Plus Specification Clinical Benefit
Primary Agent 10% CPP-ACP Restores mineral balance
Fluoride Content 900 ppm Enhances acid resistance
pH Threshold Neutral (Approx. 7.0) Prevents further demineralization
Target Site Enamel/Dentin/Cementum Versatile desensitization
Interaction Bio-available ions Buffers plaque acids

Addressing Clinical Failures and Application Errors

Patient-reported "lack of results" is frequently linked to incorrect application technique or insufficient contact time.



  • Root Cause: Excessive rinsing immediately after application.

    • Actionable Fix: Implement a "spit, don't rinse" protocol. If the patient rinses, they remove the reservoir of minerals before it has time to diffuse into the enamel subsurface.
  • Root Cause: Application over plaque biofilm.

    • Actionable Fix: Ensure the patient is educated on proper mechanical cleaning. If the paste is applied over a sticky biofilm, the CPP-ACP cannot reach the tooth surface, wasting the material.
  • Root Cause: Dry mouth inhibiting mineral transport.

    • Actionable Fix: For patients with xerostomia, use a tray system to provide a moist environment for the paste, preventing the material from dehydrating and flaking off before the contact duration is achieved.

Frequently Asked Questions



Can I use MI Paste Plus instead of toothpaste?

MI Paste Plus is a supplemental remineralizing therapy, not a replacement for daily fluoride toothpaste. Continue your standard oral hygiene routine and apply MI Paste Plus as an additional step, ideally before bedtime, to maximize the duration of mineral contact.



Is MI Paste Plus safe for children?

The product is safe for children, but it should only be used under adult supervision to ensure they do not swallow the paste. It is highly recommended for children undergoing orthodontic treatment to prevent white spot lesions around brackets.



How long does it take to see improvements in sensitivity?

Many users report a reduction in dentin hypersensitivity within 3 to 7 days of consistent daily use. Chronic sensitivity cases may require 2 to 4 weeks of regular application to achieve full remineralization and closure of open dentinal tubules.



Does MI Paste Plus whiten teeth?

MI Paste Plus does not contain bleaching agents and will not chemically lighten tooth enamel. However, by remineralizing the enamel surface, it can improve the "translucency" and luster of the teeth, which may give the appearance of a healthier, brighter smile.



Can I use this with Invisalign or whitening trays?

Yes, MI Paste Plus is an excellent adjunct for orthodontic aligners or custom whitening trays. Applying a small amount into the tray before insertion helps prevent sensitivity associated with whitening and keeps the enamel surface mineralized during orthodontic movement.

Optimize Your Dental Health Routine

Incorporate MI Paste Plus into your nightly hygiene protocol to protect against acid erosion and maintain long-term enamel integrity. Consult with your dental provider to determine the specific frequency required for your unique clinical presentation.


MI Paste Plus | GC Ortho

MI Paste Plus | GC Ortho

Read also: Rachel Brosnahan: From The Marvelous Mrs. Maisel to DC's Lois Lane
close